Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote
Box jellyfish venom causes tissue damage, pain, and death through unknown molecular mechanisms. Here, Lau et al. perform a CRISPR screen to identify genes required for venom action and use this information to develop an antidote that blocks venom-induced pain and tissue damage in vivo.
Main Authors: | Man-Tat Lau, John Manion, Jamie B. Littleboy, Lisa Oyston, Thang M. Khuong, Qiao-Ping Wang, David T. Nguyen, Daniel Hesselson, Jamie E. Seymour, G. Gregory Neely |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2019-04-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-09681-1 |
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