Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9

Whitening of brown adipose tissue inhibits osteogenic differentiation via secretion of S100A8/A9

Summary: The mechanism by which brown adipose tissue (BAT) regulates bone metabolism is unclear. Here, we reveal that BAT secretes S100A8/A9, a previously unidentified BAT adipokine (batokine), to impair bone formation. Brown adipocytes-specific knockout of Rheb (RhebBAD KO), the upstream activator...

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Bibliographic Details
Main Authors: Ting Wang, Chaoran Zhao, Jiahuan Zhang, Shengfa Li, Youming Zhang, Yan Gong, Yingyue Zhou, Lei Yan, Sheng Zhang, Zhongmin Zhang, Hongling Hu, Anling Liu, Xiaochun Bai, Zhipeng Zou
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Physiology
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224000786

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http://www.sciencedirect.com/science/article/pii/S2589004224000786

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