Alteration of cGAS-STING signaling pathway components in the mouse cortex and hippocampus during healthy brain aging

Alteration of cGAS-STING signaling pathway components in the mouse cortex and hippocampus during healthy brain aging

The cGAS-STING pathway is a pivotal element of the innate immune system, recognizing cytosolic DNA to initiate the production of type I interferons and pro-inflammatory cytokines. This study investigates the alterations of the cGAS-STING signaling components in the cortex and hippocampus of mice age...

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Bibliographic Details
Main Authors: Sergio Passarella, Shananthan Kethiswaran, Karina Brandes, I-Chin Tsai, Kristin Cebulski, Andrea Kröger, Daniela C. Dieterich, Peter Landgraf
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
cGAS-STING pathway
brain aging
autophagy
senescence
cortex
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1429005/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2024.1429005/full

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