Matrix Metalloproteinases and Blood-Brain Barrier Disruption in Acute Ischemic Stroke

Ischemic stroke continues to be one of the most challenging diseases in translational neurology. Tissue plasminogen activator (tPA) remains the only approved treatment for acute ischemic stroke, but its use is limited to the first hours after stroke onset due to an increased risk of hemorrhagic tran...

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Bibliographic Details
Main Authors: Shaheen E. Lakhan, Annette Kirchgessner, Deborah Tepper, Aidan Leonard
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-04-01
Series:Frontiers in Neurology
Subjects:
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2013.00032/full