Expression of HLA-DR by mesenchymal stromal cells in the platelet lysate era: an obsolete release criterion for MSCs?

Expression of HLA-DR by mesenchymal stromal cells in the platelet lysate era: an obsolete release criterion for MSCs?

Abstract Background According to the definition of the International Society for Cell and Gene Therapy (ISCT), mesenchymal stromal cells (MSCs) do not express HLA-DR. This phenotypic marker as a release criterion for clinical use was established at a time when MSCs were expanded in fetal bovine seru...

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Bibliographic Details
Main Authors: Zyrafete Kuçi, Natascha Piede, Kathrin Vogelsang, Lisa-Marie Pfeffermann, Sibylle Wehner, Emilia Salzmann-Manrique, Miriam Stais, Hermann Kreyenberg, Halvard Bonig, Peter Bader, Selim Kuçi
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Translational Medicine
Subjects:
Mesenchymal stromal cells
Platelet lysates
Fetal bovine serum
HLA-DR expression
MSC-release criteria
Online Access:https://doi.org/10.1186/s12967-023-04684-5

Internet

https://doi.org/10.1186/s12967-023-04684-5

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