Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide

Summary: DNA-binding transcription factors (TFs) remain challenging to target with molecular probes. Many TFs function in part through interaction with Mediator, a 26-subunit complex that controls RNA polymerase II activity genome-wide. We sought to block p53 function by disrupting the p53-Mediator...

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Bibliographic Details
Main Authors: Benjamin L. Allen, Kim Quach, Taylor Jones, Cecilia B. Levandowski, Christopher C. Ebmeier, Jonathan D. Rubin, Timothy Read, Robin D. Dowell, Alanna Schepartz, Dylan J. Taatjes
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722003825