Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs)

Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs)

Abstract Aspartate–glutamate carrier isoform 1 (AGC1) is a carrier responsible for the export of mitochondrial aspartate in exchange for cytosolic glutamate and is part of the malate–aspartate shuttle, essential for the balance of reducing equivalents in the cells. In the brain, mutations in SLC25A1...

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Bibliographic Details
Main Authors: Nicola Balboni, Giorgia Babini, Eleonora Poeta, Michele Protti, Laura Mercolini, Maria Chiara Magnifico, Simona Nicole Barile, Francesca Massenzio, Antonella Pignataro, Federico M. Giorgi, Francesco Massimo Lasorsa, Barbara Monti
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
White matter disorder
Mitochondria
Omics analysis
Oligodendrocytes
Neurodevelopment
SLC25A12/aralar1/AGC1 deficiency
Online Access:https://doi.org/10.1186/s11658-024-00563-z

Internet

https://doi.org/10.1186/s11658-024-00563-z

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