Generation of genome-edited dogs by somatic cell nuclear transfer

Generation of genome-edited dogs by somatic cell nuclear transfer

Abstract Background Canine cloning technology based on somatic cell nuclear transfer (SCNT) combined with genome-editing tools such as CRISPR-Cas9 can be used to correct pathogenic mutations in purebred dogs or to generate animal models of disease. Results We constructed a CRISPR-Cas9 vector targeti...

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Bibliographic Details
Main Authors: Dong-Ern Kim, Ji-Hye Lee, Kuk-Bin Ji, Kang-Sun Park, Tae-Young Kil, Okjae Koo, Min-Kyu Kim
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Biotechnology
Subjects:
Genome-edited dog
CRISPR-Cas9
Somatic nuclear transfer
DJ-1 knock out
Online Access:https://doi.org/10.1186/s12896-022-00749-3

Internet

https://doi.org/10.1186/s12896-022-00749-3

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