Novel roles for HMGA2 isoforms in regulating oxidative stress and sensitizing to RSL3-Induced ferroptosis in prostate cancer cells

Novel roles for HMGA2 isoforms in regulating oxidative stress and sensitizing to RSL3-Induced ferroptosis in prostate cancer cells

Oxidative stress is increased in several cancers including prostate cancer, and is currently being exploited in cancer therapy to induce ferroptosis, a novel nonapoptotic form of cell death. High mobility group A2 (HMGA2), a non-histone protein up-regulated in several cancers, can be truncated due t...

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Bibliographic Details
Main Authors: Taaliah Campbell, Ohuod Hawsawi, Veronica Henderson, Precious Dike, Bor-Jang Hwang, Yusuf Liadi, ElShaddai Z. White, Jin Zou, GuangDi Wang, Qiang Zhang, Nathan Bowen, Derrick Scott, Cimona V. Hinton, Valerie Odero-Marah
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Heliyon
Subjects:
HMGA2
Truncated HMGA2
Oxidative stress
Ferroptosis
Prostate cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023020170

Internet

http://www.sciencedirect.com/science/article/pii/S2405844023020170

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