The uPA System Differentially Alters Fibroblast Fate and Profibrotic Ability in Skin Fibrosis

The uPA System Differentially Alters Fibroblast Fate and Profibrotic Ability in Skin Fibrosis

Skin fibrosis is a common pathological feature of various diseases, and few treatment strategies are available because of the molecular pathogenesis is poorly understood. The urokinase-type plasminogen activator (uPA) system is the major serine protease system, and its components uPA, urokinase plas...

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Bibliographic Details
Main Authors: Ming-Li Zou, Ying-Ying Teng, Zhong-hua Chen, Si-Yu Liu, Yuan Jia, Kai-Wen Zhang, Jun-Jie Wu, Zheng-Dong Yuan, Xiao-Yu Tang, Shun Yu, Jun-Xing Ye, Xia Li, Xiao-Jin Zhou, Feng-Lai Yuan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
skin fibrosis
scleroderma
uPA system
systemic sclerosis
fibroblast
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.845956/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.845956/full

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