The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature

The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature

The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooperation of the transcription factors ERG and KLF2.

Bibliographic Details
Main Authors: C. Peghaire, N. P. Dufton, M. Lang, I. I. Salles-Crawley, J. Ahnström, V. Kalna, C. Raimondi, C. Pericleous, L. Inuabasi, R. Kiseleva, V. R. Muzykantov, J. C. Mason, G. M. Birdsey, A. M. Randi
Format: Article
Language:English
Published: Nature Portfolio 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12897-w

Internet

https://doi.org/10.1038/s41467-019-12897-w

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