The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooperation of the transcription factors ERG and KLF2.
Bibliographic Details
Main Authors: |
C. Peghaire,
N. P. Dufton,
M. Lang,
I. I. Salles-Crawley,
J. Ahnström,
V. Kalna,
C. Raimondi,
C. Pericleous,
L. Inuabasi,
R. Kiseleva,
V. R. Muzykantov,
J. C. Mason,
G. M. Birdsey,
A. M. Randi |
Format: | Article
|
Language: | English |
Published: |
Nature Portfolio
2019-11-01
|
Series: | Nature Communications
|
Online Access: | https://doi.org/10.1038/s41467-019-12897-w
|