The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature
The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooperation of the transcription factors ERG and KLF2.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-12897-w |
| _version_ | 1818839568523198464 |
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| author | C. Peghaire N. P. Dufton M. Lang I. I. Salles-Crawley J. Ahnström V. Kalna C. Raimondi C. Pericleous L. Inuabasi R. Kiseleva V. R. Muzykantov J. C. Mason G. M. Birdsey A. M. Randi |
| author_facet | C. Peghaire N. P. Dufton M. Lang I. I. Salles-Crawley J. Ahnström V. Kalna C. Raimondi C. Pericleous L. Inuabasi R. Kiseleva V. R. Muzykantov J. C. Mason G. M. Birdsey A. M. Randi |
| author_sort | C. Peghaire |
| collection | DOAJ |
| description | The endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooperation of the transcription factors ERG and KLF2. |
| first_indexed | 2024-12-19T03:56:22Z |
| format | Article |
| id | doaj.art-7798914f5f094e87a7d8b776f5a7230c |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T03:56:22Z |
| publishDate | 2019-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7798914f5f094e87a7d8b776f5a7230c2022-12-21T20:36:48ZengNature PortfolioNature Communications2041-17232019-11-0110111710.1038/s41467-019-12897-wThe transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculatureC. Peghaire0N. P. Dufton1M. Lang2I. I. Salles-Crawley3J. Ahnström4V. Kalna5C. Raimondi6C. Pericleous7L. Inuabasi8R. Kiseleva9V. R. Muzykantov10J. C. Mason11G. M. Birdsey12A. M. Randi13National Heart and Lung Institute, Imperial College LondonNational Heart and Lung Institute, Imperial College LondonNational Heart and Lung Institute, Imperial College LondonCentre for Haematology, Hammersmith Hospital Campus, Imperial College LondonCentre for Haematology, Hammersmith Hospital Campus, Imperial College LondonNational Heart and Lung Institute, Imperial College LondonNational Heart and Lung Institute, Imperial College LondonNational Heart and Lung Institute, Imperial College LondonNational Heart and Lung Institute, Imperial College LondonDepartment of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of MedicineDepartment of Pharmacology, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of MedicineNational Heart and Lung Institute, Imperial College LondonNational Heart and Lung Institute, Imperial College LondonNational Heart and Lung Institute, Imperial College LondonThe endothelium actively maintains an anticoagulant surface through expression of thrombomodulin. Here, Peghaire et al. identify an anti-thrombotic pathway that controls thrombomodulin expression selectively in regions of low shear stress, via cooperation of the transcription factors ERG and KLF2.https://doi.org/10.1038/s41467-019-12897-w |
| spellingShingle | C. Peghaire N. P. Dufton M. Lang I. I. Salles-Crawley J. Ahnström V. Kalna C. Raimondi C. Pericleous L. Inuabasi R. Kiseleva V. R. Muzykantov J. C. Mason G. M. Birdsey A. M. Randi The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature Nature Communications |
| title | The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature |
| title_full | The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature |
| title_fullStr | The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature |
| title_full_unstemmed | The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature |
| title_short | The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature |
| title_sort | transcription factor erg regulates a low shear stress induced anti thrombotic pathway in the microvasculature |
| url | https://doi.org/10.1038/s41467-019-12897-w |
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