Positive feedback-loop of telomerase reverse transcriptase and 15-lipoxygenase-2 promotes pulmonary hypertension.

Pulmonary hypertension (PH) is characterized with pulmonary vasoconstriction and vascular remodeling mediated by 15-lipoxygenase (15-LO)/15-hydroxyeicosatetraenoic acid (15-HETE) according to our previous studies. Meanwhile, telomerase reverse transcriptase (TERT) activity is highly correlated with...

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Bibliographic Details
Main Authors: Tingting Shen, Jun Ma, Lei Zhang, Xiufeng Yu, Mengmeng Liu, Yunlong Hou, Yanyan Wang, Cui Ma, Shuzhen Li, Daling Zhu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3871619?pdf=render