FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1
FAM76B has been reported to be a nuclear speckle-localized protein with unknown function. In this study, FAM76B was first demonstrated to inhibit the NF-κB-mediated inflammatory pathway by affecting the translocation of hnRNPA2B1 in vitro. We further showed that FAM76B suppressed inflammation in viv...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2023-08-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/85659 |
| _version_ | 1797738395983675392 |
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| author | Dongyang Wang Xiaojing Zheng Lihong Chai Junli Zhao Jiuling Zhu Yanqing Li Peiyan Yang Qinwen Mao Haibin Xia |
| author_facet | Dongyang Wang Xiaojing Zheng Lihong Chai Junli Zhao Jiuling Zhu Yanqing Li Peiyan Yang Qinwen Mao Haibin Xia |
| author_sort | Dongyang Wang |
| collection | DOAJ |
| description | FAM76B has been reported to be a nuclear speckle-localized protein with unknown function. In this study, FAM76B was first demonstrated to inhibit the NF-κB-mediated inflammatory pathway by affecting the translocation of hnRNPA2B1 in vitro. We further showed that FAM76B suppressed inflammation in vivo using a traumatic brain injury (TBI) mouse model. Lastly, FAM76B was shown to interact with hnRNPA2B1 in human tissues taken from patients with acute, organizing, and chronic TBI, and with different neurodegenerative diseases. The results suggested that FAM76B mediated neuroinflammation via influencing the translocation of hnRNPA2B1 in vivo during TBI repair and neurodegenerative diseases. In summary, we for the first time demonstrated the role of FAM76B in regulating inflammation and further showed that FAM76B could regulate the NF-κB-mediated inflammatory pathway by affecting hnRNPA2B1 translocation, which provides new information for studying the mechanism of inflammation regulation. |
| first_indexed | 2024-03-12T13:42:14Z |
| format | Article |
| id | doaj.art-779998f780b54e3f8a1a7e285dd704fe |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-12T13:42:14Z |
| publishDate | 2023-08-01 |
| publisher | eLife Sciences Publications Ltd |
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| spelling | doaj.art-779998f780b54e3f8a1a7e285dd704fe2023-08-23T14:23:06ZengeLife Sciences Publications LtdeLife2050-084X2023-08-011210.7554/eLife.85659FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1Dongyang Wang0https://orcid.org/0000-0001-9710-636XXiaojing Zheng1https://orcid.org/0009-0008-5510-5041Lihong Chai2Junli Zhao3Jiuling Zhu4Yanqing Li5Peiyan Yang6Qinwen Mao7Haibin Xia8https://orcid.org/0000-0002-2038-5759Laboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an, China; Translational Medicine Center, Northwest Women’s and Children’s Hospital, Xi'an, ChinaLaboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaLaboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaLaboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaLaboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaLaboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaLaboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaDepartment of Pathology, University of Utah, Salt Lake, United StatesLaboratory of Gene Therapy, Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi'an, ChinaFAM76B has been reported to be a nuclear speckle-localized protein with unknown function. In this study, FAM76B was first demonstrated to inhibit the NF-κB-mediated inflammatory pathway by affecting the translocation of hnRNPA2B1 in vitro. We further showed that FAM76B suppressed inflammation in vivo using a traumatic brain injury (TBI) mouse model. Lastly, FAM76B was shown to interact with hnRNPA2B1 in human tissues taken from patients with acute, organizing, and chronic TBI, and with different neurodegenerative diseases. The results suggested that FAM76B mediated neuroinflammation via influencing the translocation of hnRNPA2B1 in vivo during TBI repair and neurodegenerative diseases. In summary, we for the first time demonstrated the role of FAM76B in regulating inflammation and further showed that FAM76B could regulate the NF-κB-mediated inflammatory pathway by affecting hnRNPA2B1 translocation, which provides new information for studying the mechanism of inflammation regulation.https://elifesciences.org/articles/85659FAM76BhnRNPA2B1NF-κB pathwayinflammationneuroinflammation |
| spellingShingle | Dongyang Wang Xiaojing Zheng Lihong Chai Junli Zhao Jiuling Zhu Yanqing Li Peiyan Yang Qinwen Mao Haibin Xia FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1 eLife FAM76B hnRNPA2B1 NF-κB pathway inflammation neuroinflammation |
| title | FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1 |
| title_full | FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1 |
| title_fullStr | FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1 |
| title_full_unstemmed | FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1 |
| title_short | FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1 |
| title_sort | fam76b regulates nf κb mediated inflammatory pathway by influencing the translocation of hnrnpa2b1 |
| topic | FAM76B hnRNPA2B1 NF-κB pathway inflammation neuroinflammation |
| url | https://elifesciences.org/articles/85659 |
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