Transient multifocal genomic crisis creating chromothriptic and non-chromothriptic rearrangements in prezygotic testicular germ cells

Transient multifocal genomic crisis creating chromothriptic and non-chromothriptic rearrangements in prezygotic testicular germ cells

Abstract Background The co-occurrence of multiple de novo copy number variations (CNVs) is a rare phenomenon in the human genome. Recently, an “organismal CNV mutator phenotype” has been reported to result in transient genomic instability introducing multiple de novo CNVs in primary oocytes and earl...

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Bibliographic Details
Main Authors: Atsushi Hattori, Kohji Okamura, Yumiko Terada, Rika Tanaka, Yuko Katoh-Fukui, Yoichi Matsubara, Keiko Matsubara, Masayo Kagami, Reiko Horikawa, Maki Fukami
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Medical Genomics
Subjects:
Chromoanagenesis
Chromosomal instability
Chromothripsis
Comparative genomic hybridization
Complex genomic rearrangement
Copy number variation
Online Access:http://link.springer.com/article/10.1186/s12920-019-0526-3

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http://link.springer.com/article/10.1186/s12920-019-0526-3

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