A novel pathway links oxidative stress to loss of insulin growth factor-2 (IGF2) imprinting through NF-κB activation.

A novel pathway links oxidative stress to loss of insulin growth factor-2 (IGF2) imprinting through NF-κB activation.

Genomic imprinting is the allele-specific expression of a gene based on parental origin. Loss of imprinting(LOI) of Insulin-like Growth Factor 2 (IGF2) during aging is important in tumorigenesis, yet the regulatory mechanisms driving this event are largely unknown. In this study oxidative stress, me...

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Bibliographic Details
Main Authors: Bing Yang, Jennifer Wagner, Nathan Damaschke, Tianyu Yao, Shelly M Wuerzberger-Davis, Moon-Hee Lee, John Svaren, Shigeki Miyamoto, David F Jarrard
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3928145?pdf=render

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http://europepmc.org/articles/PMC3928145?pdf=render

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