Diethylstilbestrol Modifies the Structure of Model Membranes and Is Localized Close to the First Carbons of the Fatty Acyl Chains

Diethylstilbestrol Modifies the Structure of Model Membranes and Is Localized Close to the First Carbons of the Fatty Acyl Chains

The synthetic estrogen diethylstilbestrol (DES) is used to treat metastatic carcinomas and prostate cancer. We studied its interaction with membranes and its localization to understand its mechanism of action and side-effects. We used differential scanning calorimetry (DSC) showing that DES fluidize...

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Bibliographic Details
Main Authors: Alessio Ausili, Inés Rodríguez-González, Alejandro Torrecillas, José A. Teruel, Juan C. Gómez-Fernández
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biomolecules
Subjects:
diethylstilbestrol
membranes
<sup>31</sup>P-NMR
<sup>1</sup>H-NOESY-MAS-NMR
DSC
wide-angle X-ray diffraction (WAXD)
Online Access:https://www.mdpi.com/2218-273X/11/2/220

Internet

https://www.mdpi.com/2218-273X/11/2/220

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