Impairment of TrkB-PSD-95 signaling in Angelman syndrome.

Impairment of TrkB-PSD-95 signaling in Angelman syndrome.

Angelman syndrome (AS) is a neurodevelopment disorder characterized by severe cognitive impairment and a high rate of autism. AS is caused by disrupted neuronal expression of the maternally inherited Ube3A ubiquitin protein ligase, required for the proteasomal degradation of proteins implicated in s...

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Bibliographic Details
Main Authors: Cong Cao, Mengia S Rioult-Pedotti, Paolo Migani, Crystal J Yu, Rakesh Tiwari, Keykavous Parang, Mark R Spaller, Dennis J Goebel, John Marshall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC3570550?pdf=render

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http://europepmc.org/articles/PMC3570550?pdf=render

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