The PRC2 molecule EED is a target of epigenetic therapy for neuroblastoma

Epigenetic modifications by polycomb repressive complex (PRC) molecules appear to play a role in the tumorigenesis and aggressiveness of neuroblastoma (NB). Embryonic ectoderm development (EED) is a member of the PRC2 complex that binds to the H3K27me3 mark deposited by EZH2 via propagation on adjac...

Full description

Bibliographic Details
Main Authors: Dilibaerguli Shaliman, Hisanori Takenobu, Ryuichi P. Sugino, Miki Ohira, Takehiko Kamijo
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:European Journal of Cell Biology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933522000413