Mitochondria Targeted Antioxidant Significantly Alleviates Preeclampsia Caused by 11β-HSD2 Dysfunction via OPA1 and MtDNA Maintenance

Mitochondria Targeted Antioxidant Significantly Alleviates Preeclampsia Caused by 11β-HSD2 Dysfunction via OPA1 and MtDNA Maintenance

We have previously demonstrated that placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) dysfunction contributes to PE pathogenesis. We sought to elucidate molecular mechanisms underlying 11β-HSD2 dysfunction-induced PE and to seek potential therapeutic targets using a 11β-HSD2 dysfunction-...

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Bibliographic Details
Main Authors: Jing Long, Yan Huang, Zhengshan Tang, Yali Shan, Dou Feng, Wenqin Wang, Juan Liu, Ying Huang, Hang Gu, Dewei Guo, Ruojin Yao, Xin Ni
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Antioxidants
Subjects:
preeclampsia
mitochondria
placenta
OXPHOS
mtDNA
Online Access:https://www.mdpi.com/2076-3921/11/8/1505

Internet

https://www.mdpi.com/2076-3921/11/8/1505

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