Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells

Synergistic targeting of TrxR1 and ATM/AKT pathway in human colon cancer cells

Thioredoxin reductase 1 (TrxR1) has emerged as a promising target for cancer therapy. In our previous research, we discovered several new TrxR1 inhibitors and found that they all have excellent anti-tumor activity. At the same time, we found these TrxR1 inhibitors all lead to an increase in AKT phos...

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Bibliographic Details
Main Authors: Xin Shen, Yiqun Xia, Hui Lu, Peisen Zheng, Junqi Wang, Yinghua Chen, Chenxin Xu, Chenyu Qiu, Yafei Zhang, Zhongxiang Xiao, Peng Zou, Ri Cui, Daoyong Ni
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
TrxR1
AKT
ROS
Autophagy
Colon cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224003913

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http://www.sciencedirect.com/science/article/pii/S0753332224003913

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