Lung delivery of MSCs expressing anti-cancer protein TRAIL visualised with 89Zr-oxine PET-CT

Lung delivery of MSCs expressing anti-cancer protein TRAIL visualised with 89Zr-oxine PET-CT

Abstract Background MSCTRAIL is a cell-based therapy consisting of human allogeneic umbilical cord-derived MSCs genetically modified to express the anti-cancer protein TRAIL. Though cell-based therapies are typically designed with a target tissue in mind, delivery is rarely assessed due to a lack of...

Full description

Bibliographic Details
Main Authors: P. Stephen Patrick, Krishna K. Kolluri, May Zaw Thin, Adam Edwards, Elizabeth K. Sage, Tom Sanderson, Benjamin D. Weil, John C. Dickson, Mark F. Lythgoe, Mark Lowdell, Sam M. Janes, Tammy L. Kalber
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Stem Cell Research & Therapy
Subjects:
PET-CT
Cell tracking
TRAIL
89Zr-oxine
Cord-derived MSCs
Cell therapy
Online Access:http://link.springer.com/article/10.1186/s13287-020-01770-z

Internet

http://link.springer.com/article/10.1186/s13287-020-01770-z

Similar Items