HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism: suppression by gp120 specific small interfering RNA.

HIV-1 gp120 induces expression of IL-6 through a nuclear factor-kappa B-dependent mechanism: suppression by gp120 specific small interfering RNA.

In addition to its role in virus entry, HIV-1 gp120 has also been implicated in HIV-associated neurocognitive disorders. However, the mechanism(s) responsible for gp120-mediated neuroinflammation remain undefined. In view of increased levels of IL-6 in HIV-positive individuals with neurological mani...

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Bibliographic Details
Main Authors: Ankit Shah, Ashish S Verma, Kalpeshkumar H Patel, Richard Noel, Vanessa Rivera-Amill, Peter S Silverstein, Suman Chaudhary, Hari K Bhat, Leonidas Stamatatos, Dhirendra P Singh, Shilpa Buch, Anil Kumar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3119684?pdf=render

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http://europepmc.org/articles/PMC3119684?pdf=render

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