Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism

Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism

Abstract Microglial abnormality and heterogeneity are observed in autism spectrum disorder (ASD) patients and animal models of ASD. Microglial depletion by colony stimulating factor 1-receptor (CSF1R) inhibition has been proved to improve autism-like behaviors in maternal immune activation mouse off...

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Bibliographic Details
Main Authors: Jiao Meng, Pengming Pan, Gengshuo Guo, Anqi Chen, Xiangbao Meng, Heli Liu
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Journal of Neuroinflammation
Subjects:
Autism
Microglia
CSF1R inhibitor
Cntnap2 knockout mouse
Valproic acid-exposed mouse
Pharmacological heterogeneity
Online Access:https://doi.org/10.1186/s12974-024-03259-5

Internet

https://doi.org/10.1186/s12974-024-03259-5

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