Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks

Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks

Presenilin-2 (PS2) is one of the three proteins that are dominantly mutated in familial Alzheimer’s disease (FAD). It forms the catalytic core of the γ-secretase complex—a function shared with its homolog presenilin-1 (PS1)—the enzyme ultimately responsible of amyloid-β (Aβ) formation. Besides its e...

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Bibliographic Details
Main Authors: Paola Pizzo, Emy Basso, Riccardo Filadi, Elisa Greotti, Alessandro Leparulo, Diana Pendin, Nelly Redolfi, Michela Rossini, Nicola Vajente, Tullio Pozzan, Cristina Fasolato
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
presenilin-2
calcium signalling
Alzheimer’s disease mouse models
SOCE
mitochondria
autophagy
Online Access:https://www.mdpi.com/2073-4409/9/10/2166

Internet

https://www.mdpi.com/2073-4409/9/10/2166

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