Assessing structure and disorder prediction tools for de novo emerged proteins in the age of machine learning [version 1; peer review: 2 approved]

Background: De novo protein coding genes emerge from scratch in the non-coding regions of the genome and have, per definition, no homology to other genes. Therefore, their encoded de novo proteins belong to the so-called "dark protein space". So far, only four de novo protein structures ha...

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Bibliographic Details
Main Authors: Erich Bornberg-Bauer, Lars Eicholt, Margaux Aubel
Format: Article
Language:English
Published: F1000 Research Ltd 2023-03-01
Series:F1000Research
Subjects:
Online Access:https://f1000research.com/articles/12-347/v1