Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3

Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3

Tumor suppressor p53-directed apoptosis triggers loss of normal cells, which contributes to the side-effects from anticancer therapies. Thus, small molecules with potential to downregulate the activation of p53 could minimize pathology emerging from anticancer therapies. Acetylation of p53 by the hi...

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Bibliographic Details
Main Authors: Adam S. Vincek, Jigneshkumar Patel, Anbalagan Jaganathan, Antonia Green, Valerie Pierre-Louis, Vimal Arora, Jill Rehmann, Mihaly Mezei, Ming-Ming Zhou, Michael Ohlmeyer, Shiraz Mujtaba
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
lysine acetylation
transcriptional coactivator CBP
histone acetyltransferase
cy-C5-curcuminoids
p53 acetylation
histone acetylation
methylation
Online Access:http://www.mdpi.com/1420-3049/23/8/1930

Internet

http://www.mdpi.com/1420-3049/23/8/1930

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