Microcin MccI47 selectively inhibits enteric bacteria and reduces carbapenem-resistant Klebsiella pneumoniae colonization in vivo when administered via an engineered live biotherapeutic

Microcin MccI47 selectively inhibits enteric bacteria and reduces carbapenem-resistant Klebsiella pneumoniae colonization in vivo when administered via an engineered live biotherapeutic

The gastrointestinal (GI) tract is the reservoir for multidrug resistant (MDR) pathogens, specifically carbapenem-resistant (CR) Klebsiella pneumoniae and other Enterobacteriaceae, which often lead to the spread of antimicrobial resistance genes, severe extraintestinal infections, and lethal outcome...

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Bibliographic Details
Main Authors: Benedikt M. Mortzfeld, Jacob D. Palmer, Shakti K. Bhattarai, Haley L. Dupre, Regino Mercado-Lubio, Mark W. Silby, Corinna Bang, Beth A. McCormick, Vanni Bucci
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Gut Microbes
Subjects:
Carbapenem-resistant Klebsiella
engineered live biotherapeutics
microcins
E. coli Nissle 1917
enterobacteriaceae
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2022.2127633

Internet

https://www.tandfonline.com/doi/10.1080/19490976.2022.2127633

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