A versatile way for the synthesis of monomethylamines by reduction of N-substituted carbonylimidazoles with the NaBH4/I2 system

A versatile way for the synthesis of monomethylamines by reduction of N-substituted carbonylimidazoles with the NaBH4/I2 system

An economical and versatile protocol for the one-pot synthesis of monomethylamines by reduction of N-substituted carbonylimidazoles with NaBH4/I2 in THF at reflux temperature is described. This method used no special catalyst and various monomethylamines can be easily obtained in moderate to good yi...

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Bibliographic Details
Main Authors: Lin Chen, Xuan Zhou, Zhiyong Chen, Changxu Wang, Shunjie Wang, Hanbing Teng
Format: Article
Language:English
Published: Beilstein-Institut 2022-08-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
amines
carboxylic acids
isocyanates
monomethylamines
n-substituted carbonylimidazoles
reduction
Online Access:https://doi.org/10.3762/bjoc.18.104

Internet

https://doi.org/10.3762/bjoc.18.104

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