Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity

Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity

PI3K-related kinases (PIKKs) are large Serine/Threonine (Ser/Thr)-protein kinases central to the regulation of many fundamental cellular processes. PIKK family member SMG1 orchestrates progression of an RNA quality control pathway, termed nonsense-mediated mRNA decay (NMD), by phosphorylating the NM...

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Bibliographic Details
Main Authors: Lukas M Langer, Yair Gat, Fabien Bonneau, Elena Conti
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
PIKK
nonsense-mediated mRNA decay
Cryo-EM
phosphorylation
RNA quality control
Online Access:https://elifesciences.org/articles/57127

Internet

https://elifesciences.org/articles/57127

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