Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection

Niemann-Pick C1 (NPC1) is a lysosomal membrane protein that exports cholesterol derived from receptor-mediated uptake of LDL, and it also mediates cellular entry of Ebola virus. Cholesterol export is inhibited by nanomolar concentrations of U18666A, a cationic sterol. To identify the target of U1866...

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Bibliographic Details
Main Authors: Feiran Lu, Qiren Liang, Lina Abi-Mosleh, Akash Das, Jef K De Brabander, Joseph L Goldstein, Michael S Brown
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
Niemann-Pick C1
cholesterol transport
endosomes/lysosomes
U18666A
crosslinking
sterol-sensing domain
Online Access:https://elifesciences.org/articles/12177

Internet

https://elifesciences.org/articles/12177

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