Regulation of O-Linked N-Acetyl Glucosamine Transferase (OGT) through E6 Stimulation of the Ubiquitin Ligase Activity of E6AP

Regulation of O-Linked N-Acetyl Glucosamine Transferase (OGT) through E6 Stimulation of the Ubiquitin Ligase Activity of E6AP

Glycosyltransferase OGT catalyzes the conjugation of O-linked β-D-N-acetylglucosamine (O-GlcNAc) to Ser and Thr residues of the cellular proteins and regulates many key processes in the cell. Here, we report the identification of OGT as a ubiquitination target of HECT-type E3 ubiquitin (UB) ligase E...

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Bibliographic Details
Main Authors: Kangli Peng, Ruochuan Liu, Caiwei Jia, Yiyang Wang, Geon H. Jeong, Li Zhou, Ronggui Hu, Hiroaki Kiyokawa, Jun Yin, Bo Zhao
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
ubiquitin
ubiquitination
O-GlcNAcylation
human papillomavirus
E6AP
E6
Online Access:https://www.mdpi.com/1422-0067/22/19/10286

Internet

https://www.mdpi.com/1422-0067/22/19/10286

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