Bile Acid Sequestrant, Sevelamer Ameliorates Hepatic Fibrosis with Reduced Overload of Endogenous Lipopolysaccharide in Experimental Nonalcoholic Steatohepatitis

Bile Acid Sequestrant, Sevelamer Ameliorates Hepatic Fibrosis with Reduced Overload of Endogenous Lipopolysaccharide in Experimental Nonalcoholic Steatohepatitis

Despite the use of various pharmacotherapeutic strategies, fibrosis due to nonalcoholic steatohepatitis (NASH) remains an unsatisfied clinical issue. We investigated the effect of sevelamer, a hydrophilic bile acid sequestrant, on hepatic fibrosis in a murine NASH model. Male C57BL/6J mice were fed...

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Bibliographic Details
Main Authors: Yuki Tsuji, Kosuke Kaji, Mitsuteru Kitade, Daisuke Kaya, Koh Kitagawa, Takahiro Ozutsumi, Yukihisa Fujinaga, Hiroaki Takaya, Hideto Kawaratani, Tadashi Namisaki, Kei Moriya, Takemi Akahane, Hitoshi Yoshiji
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Microorganisms
Subjects:
nonalcoholic steatohepatitis
sevelamer
lipopolysaccharide
toll-like receptor 4
Online Access:https://www.mdpi.com/2076-2607/8/6/925

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https://www.mdpi.com/2076-2607/8/6/925

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