Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution

Preparation of 6-Substituted Quinoxaline JSP-1 Inhibitors by Microwave Accelerated Nucleophilic Substitution

A small library of 6-aminoquinoxalines has been prepared by nucleophilic substitution of 6-fluoroquinoxaline with amines and nitrogen-containing heterocycles under computer-controlled microwave irradiation. Some compounds were found to be potent inhibitors of JNK Stimulatory Phosphatase-1 (JSP-1) in...

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Bibliographic Details
Main Authors: Jingkang Shen, Jia Li, Jian Liu, Yongliang Zhang, Jingya Li, Xin Wang, Xin Li, Beiying Qiu, Li Zhang
Format: Article
Language:English
Published: MDPI AG 2006-12-01
Series:Molecules
Subjects:
Microwave irradiation
nucleophilic substitution
6-substituted quinoxalines
JSP-1.
Online Access:http://www.mdpi.com/1420-3049/11/12/988/

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http://www.mdpi.com/1420-3049/11/12/988/

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