Identification of Novel 4′-<i>O</i>-Demethyl-epipodophyllotoxin Derivatives as Antitumor Agents Targeting Topoisomerase II
C4 variation of 4′-<i>O</i>-demethyl-epipodophyllotoxin (DMEP) is an effective approach to optimize the antitumor spectra of this compound class. Accordingly, two series of novel DMEP derivatives were synthesized, and as expected, the antitumor spectra of these derivatives varied with di...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/15/5029 |