New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4

New Pharmacological Strategies against Pancreatic Adenocarcinoma: The Multifunctional Thiosemicarbazone FA4

A new sigma-2 (σ2) receptor ligand (<b>FA4</b>) was efficiently synthesized and evaluated for cytotoxic, proapoptotic, and antimigratory activity on pancreatic ductal adenocarcinoma (PDAC) primary cell cultures, which restrained the aggressive and chemoresistant behavior of PDAC. This co...

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Bibliographic Details
Main Authors: Dario P. Anobile, Mauro Niso, Adrian Puerta, Stephanie M. Fraga Rodrigues, Francesca S. Abatematteo, Amir Avan, Carmen Abate, Chiara Riganti, Elisa Giovannetti
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
multifunctional thiosemicarbazone
σ-2 receptor ligands
pancreatic cancer primary cultures
chemoresistance
migration
Online Access:https://www.mdpi.com/1420-3049/27/5/1682

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https://www.mdpi.com/1420-3049/27/5/1682

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