Bispecific Anti-HIV Immunoadhesins That Bind Gp120 and Gp41 Have Broad and Potent HIV-Neutralizing Activity

Bispecific Anti-HIV Immunoadhesins That Bind Gp120 and Gp41 Have Broad and Potent HIV-Neutralizing Activity

We have constructed bispecific immunoglobulin-like immunoadhesins that bind to both the HIV-envelope glycoproteins: gp120 and gp41. These immunoadhesins have N terminal domains of human CD4 engrafted onto the N-terminus of the heavy chain of human anti-gp41 mAb 7B2. Binding of these constructs to re...

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Bibliographic Details
Main Authors: Seth H. Pincus, Ryan B. Craig, Lauren Weachter, Celia C. LaBranche, Rafiq Nabi, Connie Watt, Mark Raymond, Tami Peters, Kejing Song, Grace A. Maresh, David C. Montefiori, Pamela A. Kozlowski
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Vaccines
Subjects:
HIV
immunotherapy
immunoadhesin
AIDS
Online Access:https://www.mdpi.com/2076-393X/9/7/774

Internet

https://www.mdpi.com/2076-393X/9/7/774

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