The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP<sup>5+</sup>, Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined with Cisplatin

The Redox-Active Manganese(III) Porphyrin, MnTnBuOE-2-PyP<sup>5+</sup>, Impairs the Migration and Invasion of Non-Small Cell Lung Cancer Cells, Either Alone or Combined with Cisplatin

Manganese(III) porphyrin MnTnBuOE-2-PyP<sup>5+</sup> (MnBuOE, BMX-001) is a third-generation redox-active cationic substituted pyridylporphyrin-based drug with a good safety/toxicity profile that has been studied in several types of cancer. It is currently in four phase I/II clinical tri...

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Bibliographic Details
Main Authors: Rita B. Soares, Rita Manguinhas, João G. Costa, Nuno Saraiva, Nuno Gil, Rafael Rosell, Sérgio P. Camões, Ines Batinic-Haberle, Ivan Spasojevic, Matilde Castro, Joana P. Miranda, Paula Guedes de Pinho, Ana S. Fernandes, Nuno G. Oliveira
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cancers
Subjects:
SOD mimic
Mn porphyrin
MnTnBuOE-2-PyP<sup>5+</sup> (BMX-001)
non-small cell lung cancer
cisplatin
migration
Online Access:https://www.mdpi.com/2072-6694/15/15/3814

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https://www.mdpi.com/2072-6694/15/15/3814

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