Kurarinone from <i>Sophora Flavescens</i> Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation

Kurarinone from <i>Sophora Flavescens</i> Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation

In response to cellular stresses, activating transcriptional factor 4 (ATF4) regulates the expression of both stress-relieving genes and apoptosis-inducing genes, eliciting cell fate determination. Since pharmacological activation of ATF4 exerts potent anti-tumor effects, modulators of ATF4 activati...

Full description

Bibliographic Details
Main Authors: Sakiko Nishikawa, Yuka Itoh, Muneshige Tokugawa, Yasumichi Inoue, Ken-ichi Nakashima, Yuka Hori, Chiharu Miyajima, Kou Yoshida, Daisuke Morishita, Nobumichi Ohoka, Makoto Inoue, Hajime Mizukami, Toshiaki Makino, Hidetoshi Hayashi
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Molecules
Subjects:
ATF4
cancer
ISR
kurarinone
PERK
<i>Sophora flavescens</i>
TRB3
Online Access:https://www.mdpi.com/1420-3049/24/17/3110

Internet

https://www.mdpi.com/1420-3049/24/17/3110

Similar Items