Nutrient Excess and AMPK Downregulation in Incubated Skeletal Muscle and Muscle of Glucose Infused Rats.

We have previously shown that incubation for 1h with excess glucose or leucine causes insulin resistance in rat extensor digitorum longus (EDL) muscle by inhibiting AMP-activated protein kinase (AMPK). To examine the events that precede and follow these changes, studies were performed in rat EDL inc...

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Bibliographic Details
Main Authors: Kimberly A Coughlan, Thomas W Balon, Rudy J Valentine, Robert Petrocelli, Vera Schultz, Amanda Brandon, Gregory J Cooney, Edward W Kraegen, Neil B Ruderman, Asish K Saha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4440828?pdf=render