Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177<sup>®</sup> (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction

Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177<sup>®</sup> (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction

Interleukin-1β (IL-1β), a product of the NLRP3 inflammasome, modulates cardiac contractility and diastolic function. We proposed that OLT1177<sup>®</sup> (dapansutrile), a novel NLRP3 inhibitor, could preserve contractile reserve and diastolic function after myocardial infarction (MI). W...

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Bibliographic Details
Main Authors: Joseph Aliaga, Aldo Bonaventura, Eleonora Mezzaroma, Yogesh Dhakal, Adolfo Gabriele Mauro, Antonio Abbate, Stefano Toldo
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
acute myocardial infarction
inflammation
inflammasome
NLRP3
heart failure
Online Access:https://www.mdpi.com/1420-3049/26/12/3534

Internet

https://www.mdpi.com/1420-3049/26/12/3534

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