Identification of lysyl oxidase as an adipocyte-secreted mediator that promotes a partial mesenchymal-to-epithelial transition in MDA-MB-231 cells

Identification of lysyl oxidase as an adipocyte-secreted mediator that promotes a partial mesenchymal-to-epithelial transition in MDA-MB-231 cells

Aim: Breast cancer (BC) is the most common cancer in women worldwide, where adiposity has been linked to BC morbidity. In general, obese premenopausal women diagnosed with triple-negative BC (TNBC) tend to have larger tumours with more metastases, particularly to the bone marrow, and worse prognosis...

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Bibliographic Details
Main Authors: Cassidy M. Van Stiphout, Grant Kelly, Nikitha K. Pallegar, Eman Elbakry, Ana Valeria Vilchis-Celis, Sherri L. Christian, Alicia M. Viloria-Petit
Format: Article
Language:English
Published: Open Exploration Publishing Inc. 2024-01-01
Series:Exploration of Targeted Anti-tumor Therapy
Subjects:
lysyl oxidase
mesenchymal-to-epithelial transition
metastasis
3-dimensional culture
extracellular matrix
adipocytes
triple-negative breast cancer
obesity
Online Access:https://www.explorationpub.com/Journals/etat/Article/1002201

Internet

https://www.explorationpub.com/Journals/etat/Article/1002201

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