Loss of GTF2I promotes neuronal apoptosis and synaptic reduction in human cellular models of neurodevelopment

Loss of GTF2I promotes neuronal apoptosis and synaptic reduction in human cellular models of neurodevelopment

Summary: Individuals with Williams syndrome (WS), a neurodevelopmental disorder caused by hemizygous loss of 26–28 genes at 7q11.23, characteristically portray a hypersocial phenotype. Copy-number variations and mutations in one of these genes, GTF2I, are associated with altered sociality and are pr...

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Bibliographic Details
Main Authors: Jason W. Adams, Annabelle Vinokur, Janaína S. de Souza, Charles Austria, Bruno S. Guerra, Roberto H. Herai, Karl J. Wahlin, Alysson R. Muotri
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Neuroscience
CP: Developmental biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724001955

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http://www.sciencedirect.com/science/article/pii/S2211124724001955

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