Organophosphorus S-adenosyl-L-methionine mimetics: synthesis, stability, and substrate properties

Organophosphorus S-adenosyl-L-methionine mimetics: synthesis, stability, and substrate properties

S-Adenosyl-l-methionine (SAM)-mediated methylation of biomolecules controls their function and regulates numerous vital intracellular processes. Analogs of SAM with a reporter group in place of the S-methyl group are widely used to study these processes. However, many of these analogs are chemically...

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Bibliographic Details
Main Authors: Alexander Yu Rudenko, Sofia S. Mariasina, Anastasiia K. Bolikhova, Maxim V. Nikulin, Ratislav M. Ozhiganov, Vasiliy G. Vasil’ev, Yuri A. Ikhalaynen, Anastasia L. Khandazhinskaya, Maxim A. Khomutov, Peter V. Sergiev, Alex R. Khomutov, Vladimir I. Polshakov
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-08-01
Series:Frontiers in Chemistry
Subjects:
S-adenosyl-L-methionine
SAM analogs
halide methyltransferase
MAT2A
COMT
WBSCR27
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2024.1448747/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2024.1448747/full

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