Nrf2−/− regulated lung DNA demethylation and CYP2E1 DNA methylation under PM2.5 exposure

Nrf2−/− regulated lung DNA demethylation and CYP2E1 DNA methylation under PM2.5 exposure

Cytochrome P450 (CYP450) can mediate fine particulate matter (PM2.5) exposure leading to lung injury. Nuclear factor E2-related factor 2 (Nrf2) can regulate CYP450 expression; however, the mechanism by which Nrf2−/− (KO) regulates CYP450 expression via methylation of its promoter after PM2.5 exposur...

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Bibliographic Details
Main Authors: Mengjie Wu, Menghui Jiang, Hao Ding, Siying Tang, Daochuan Li, Jingbo Pi, Rong Zhang, Wen Chen, Rui Chen, Yuxin Zheng, Jinmei Piao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Genetics
Subjects:
PM2.5
Nrf2
CYP2E1
DNA methylation
Tet3
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1144903/full

Internet

https://www.frontiersin.org/articles/10.3389/fgene.2023.1144903/full

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