ANGPTL2‐mediated epigenetic repression of MHC‐I in tumor cells accelerates tumor immune evasion

ANGPTL2‐mediated epigenetic repression of MHC‐I in tumor cells accelerates tumor immune evasion

Loss or downregulation of major histocompatibility complex class I (MHC‐I) contributes to tumor immune evasion. We previously demonstrated that angiopoietin‐like protein 2 (ANGPTL2) promotes tumor progression using a Xp11.2 translocation renal cell carcinoma (tRCC) mouse model. However, molecular me...

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Bibliographic Details
Main Authors: Tsuyoshi Kadomatsu, Chiaki Hara, Ryoma Kurahashi, Haruki Horiguchi, Jun Morinaga, Keishi Miyata, Sohtaro Kurano, Hisashi Kanemaru, Satoshi Fukushima, Kimi Araki, Masaya Baba, W. Marston Linehan, Tomomi Kamba, Yuichi Oike
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Molecular Oncology
Subjects:
ANGPTL2
H3K27me3
MHC‐I
PRC2
tumor immune evasion
Online Access:https://doi.org/10.1002/1878-0261.13490

Internet

https://doi.org/10.1002/1878-0261.13490

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