Lyophilized Hybrid Nanostructured Lipid Carriers to Enhance the Cellular Uptake of Verapamil: Statistical Optimization and In Vitro Evaluation

Lyophilized Hybrid Nanostructured Lipid Carriers to Enhance the Cellular Uptake of Verapamil: Statistical Optimization and In Vitro Evaluation

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Abstract Verapamil is a calcium channel blocker and highly effective in the treatment of hypertension, angina pectoris, and other diseases. However, the drug has a low bioavailability of 20 to 35% due to the first pass effect. The main objective of this study was to develop hybrid verapamil-dextran...

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Bibliographic Details
Main Authors: Arshad Ali Khan, Ibrahim M. Abdulbaqi, Reem Abou Assi, Vikneswaran Murugaiyah, Yusrida Darwis
Format: Article
Language:English
Published: SpringerOpen 2018-10-01
Series:Nanoscale Research Letters
Subjects:
Verapamil hydrochloride
Dextran sulfate sodium
Nanostructured lipid carriers
Factorial design
Caco-2 cell line
Cellular uptake
Online Access:http://link.springer.com/article/10.1186/s11671-018-2744-6

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http://link.springer.com/article/10.1186/s11671-018-2744-6

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