Acetylation discriminates disease-specific tau deposition

Abstract Pathogenic aggregation of the protein tau is a hallmark of Alzheimer’s disease and several other tauopathies. Tauopathies are characterized by the deposition of specific tau isoforms as disease-related tau filament structures. The molecular processes that determine isoform-specific depositi...

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Bibliographic Details
Main Authors: Pijush Chakraborty, Gwladys Rivière, Alina Hebestreit, Alain Ibáñez de Opakua, Ina M. Vorberg, Loren B. Andreas, Markus Zweckstetter
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41672-1