Absence of Glutathione Peroxidase 4 Affects Tumor Angiogenesis through Increased 12/15-Lipoxygenase Activity

Absence of Glutathione Peroxidase 4 Affects Tumor Angiogenesis through Increased 12/15-Lipoxygenase Activity

The selenoenzyme glutathione peroxidase 4 (GPx4) has been described to control specific cyclooxygenases (COXs) and lipoxygenases (LOXs) that exert substantiated functions in tumor growth and angiogenesis. Therefore, we hypothesized a putative regulatory role of GPx4 during tumor progression and crea...

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Bibliographic Details
Main Authors: Manuela Schneider, Markus Wortmann, Pankaj Kumar Mandal, Warangkana Arpornchayanon, Katharina Jannasch, Frauke Alves, Sebastian Strieth, Marcus Conrad, Heike Beck
Format: Article
Language:English
Published: Elsevier 2010-03-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558610801046

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http://www.sciencedirect.com/science/article/pii/S1476558610801046

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